Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder

M Giménez; A Guinea-Izquierdo; V Villalta-Gil; I Martínez-Zalacaín; C Segalàs; M Subirà; E Real; J Pujol; BJ Harrison; JM Haro; JR Sato; MQ Hoexter; N Cardoner; P Alonso; JM Menchón; C Soriano-Mas

Journal article

Brain alterations in low-frequency fluctuations across multiple bands in obsessive compulsive disorder

M Giménez, A Guinea-Izquierdo, V Villalta-Gil, I Martínez-Zalacaín, C Segalàs, M Subirà, E Real, J Pujol, BJ Harrison, JM Haro, JR Sato, MQ Hoexter, N Cardoner, P Alonso, JM Menchón, C Soriano-Mas

Brain Imaging and Behavior | SPRINGER | Published : 2017

DOI: 10.1007/s11682-016-9601-y

Abstract

The extent of functional abnormalities in frontal-subcortical circuits in obsessive-compulsive disorder (OCD) is still unclear. Although neuroimaging studies, in general, and resting-state functional Magnetic Resonance Imaging (rs-fMRI), in particular, have provided relevant information regarding such alterations, rs-fMRI studies have been typically limited to the analysis of between-region functional connectivity alterations at low-frequency signal fluctuations (i.e., <0.08 Hz). Conversely, the local attributes of Blood Oxygen Level Dependent (BOLD) signal across different frequency bands have been seldom studied, although they may provide valuable information. Here, we evaluated local alte..

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University of Melbourne Researchers

Ben Harrison Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by the Carlos III Health Institute (PI09/01331, PI10/01753, PI10/01003, CP10/00604, PI13/01958, and CIBER-CB06/03/0034), FEDER funds ("a way to build Europe"), and the Agency for Administration of University and Research (AGAUR, Barcelona; 2014SGR1672). Dr. Soriano-Mas is funded by a "Miguel Servet" contract (CP10/00604), Dr. Real by a "Juan Rodes" contract (J14/00038) and Dr. Subira by a "Rio Hortega" contract (CM15/00189) from the Carlos III Health Institute. Mr. Guinea-Izquierdo is supported by a Ministry of Education, Culture and Sport grant (FPU014/04822). Dr. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Project Grant (Grant # 1025619) and a NHMRC Clinical Career Development Fellowship (Grant # 628509). Dr. Sato is supported by Sao Paulo Research Foundation - Brazil (FAPESP Grant # 2013/10498-6); Dr. Hoexter is supported by Sao Paulo Research Foundation -Brazil (FAPESP Grant # 2013/16864-4).